منابع مشابه
Linear motifs confer functional diversity onto splice variants
The pre-translational modification of messenger ribonucleic acids (mRNAs) by alternative promoter usage and alternative splicing is an important source of pleiotropy. Despite intensive efforts, our understanding of the functional implications of this dynamically created diversity is still incomplete. Using the available knowledge of interaction modules, particularly within intrinsically disorde...
متن کاملIdentification of polymorphic motifs using probabilistic search algorithms.
The problem of identifying motifs comprising nucleotides at a set of polymorphic DNA sites, not necessarily contiguous, arises in many human genetic problems. However, when the sites are not contiguous, no efficient algorithm exists for polymorphic motif identification. A search based on complete enumeration is computationally inefficient. We have developed probabilistic search algorithms to di...
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As a major driving force of genome evolution, transposons have been deviating from their original connotation as "junk" DNA ever since their important roles were revealed. The recently discovered Helitron transposons have been investigated in diverse eukaryotic genomes because of their remarkable gene-capture ability and other features that are crucial to our current understanding of genome dyn...
متن کاملDeterminants of the Usage of Splice-Associated cis-Motifs Predict the Distribution of Human Pathogenic SNPs
Where in genes do pathogenic mutations tend to occur and does this provide clues as to the possible underlying mechanisms by which single nucleotide polymorphisms (SNPs) cause disease? As splice-disrupting mutations tend to occur predominantly at exon ends, known also to be hot spots of cis-exonic splice control elements, we examine the relationship between the relative density of such exonic c...
متن کاملClathrin light chains LCA and LCB are similar, polymorphic, and share repeated heptad motifs.
The clathrin light chains fall into two major classes, LCA and LCB. In an intact clathrin triskelion, one light chain, of either class, is bound to the proximal segment of a heavy chain leg. Analysis of rat brain and liver complementary DNA clones for LCA and LCB shows that the two light chain classes are closely related. There appear to be several members of each class having deletions of vary...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2001
ISSN: 1478-6362
DOI: 10.1186/ar-2001-68061